Metabolic Peptides
NAD+
Research Grade≥99% PurityLyophilized
Nicotinamide adenine dinucleotide, a coenzyme studied for its role in cellular metabolism and redox signaling pathways.
Dosage
$70.00
Quantity
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Research Summary
NAD+
Published research data and clinical observations
🔬
Research Phase
Human RCTs completed
💉
Administration
Multiple routes studied
🧬
Key Mechanism
500+ enzymatic reactions
📄
Publications
Peer-reviewed papers
👥
Subjects Studied
Human + animal models
What Makes NAD+ Different?
The Science, Simplified
The Cell's Energy Currency
NAD+ isn't a drug — it's a coenzyme found in every living cell, required for over 500 enzymatic reactions. Your body uses it to power three critical systems that all decline with age.
SIRT
Primary
Sirtuins (SIRT1-7)
DNA repair enzymes
Gene silencing control
Metabolic regulation
Longevity pathway
PARP
Critical
DNA Damage Repair
Poly-ADP-ribose polymerase
Fixes DNA strand breaks
Genome stability
Cancer prevention pathway
ETC
Essential
Mitochondrial Energy
Complex I electron transport
ATP energy production
Cellular respiration
Metabolic efficiency
WHY LEVELS DECLINE WITH AGE
The NAD+ Decline Problem
NAD+ levels drop ~50% between ages 40-60. This decline is now considered a hallmark of aging by leading researchers:
Every major age-related pathway — DNA repair, mitochondrial function, inflammation — depends on NAD+ as fuel. Less NAD+ means all three decline together.
IV NAD+2-10x increase (hours)
NMN (oral)1.5-2x (sustained)
NR / Niacin1.2-1.5x (sustained)
What Researchers Observed
60%
NAD+ increase in whole blood
Martens et al. (2018) NR supplementation, 6-week RCT
60%
68%
85%
52%
Key Milestones Achieved
85%
Dose-dependent, confirmed in RCT
95%
No serious adverse events (Martens 2018)
45%
Insulin sensitivity, lipid panels
For context:NAD+ levels decline ~1-2% per year after age 40 (Massudi et al. 2012). The 2018 Martens et al. RCT (n=30, crossover design, 2x6 weeks) confirmed NR supplementation safely and effectively raises NAD+ in healthy adults aged 55-79. Larger trials are ongoing.
Compound Information
Technical specifications
❄️ Storage Requirements
Stability Information
Keep dryProtect from lightKeep refrigerated
Lyophilized (powder)
-20°C · 24+ months
Reconstituted
2-8°C · ~7 days
📋 Development Status
Where It Stands
Phase I/IIResearch Use Only
DeveloperMultiple institutions
Trial ProgramNAD+ precursor trials
ResultsHuman RCTs completed (NR/NMN)
This page summarizes published research for informational purposes only. These products are sold exclusively as research chemicals and are not intended for human consumption. Always consult peer-reviewed literature for complete study details.
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