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MOTS-c 10 mg — research peptide vial
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MOTS-c

Research Grade≥99% PurityLyophilized

A mitochondrial-derived peptide studied for metabolic homeostasis and exercise physiology.

Dosage
$75.00
Quantity
1
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Certificate of Analysis

Third Party Tested by Freedom Diagnostics

LATESTSELECTED DOSAGE
99.67%
Purity
Variant10 mg
Lot #VRP-MOT10-001
Labeled10 mg
Actual10.22mg
TestedFeb 3, 2026
View COA

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Research Summary

MOTS-c

Published research data and clinical observations

🔬
Preclinical
Research Phase
First-in-class MDP
💉
SC / IP
Administration
Systemic injection
🧬
AMPK Activation
Key Mechanism
Folate-AICAR-AMPK axis
📄
35+
Publications
Including Nature Comms
🐁
400+
Subjects Studied
Rodent + human correlative

What Makes MOTS-c Different?

The Science, Simplified

Your Mitochondria Talk to Your Genes

MOTS-c is one of only a handful of peptides encoded by mitochondrial DNA — not nuclear DNA. It's essentially a message from your mitochondria to your cell nucleus, telling it to activate metabolic defense programs. This is an entirely new class of cellular signaling.

AMPK
Primary
Energy Sensor Activation
Master metabolic switch
Folate-AICAR pathway
Exercise-mimetic effects
Insulin sensitivity boost
Nuc
Unique
Nuclear Translocation
Moves to cell nucleus
Activates ARE genes
Antioxidant response
Stress adaptation
Mito
Origin
Mitochondrial Encoded
Encoded by mtDNA
Declines with age
Centenarian variant exists
Exercise increases levels
WHY MITOCHONDRIAL ORIGIN MATTERS

Exercise in a Peptide

MOTS-c has exercise-mimetic properties — it activates the same AMPK pathway that physical exercise does. But it's also linked to exceptional longevity:

A genetic variant of MOTS-c (m.1382A>C) is significantly enriched in Japanese centenarians — suggesting this peptide may be a key to healthy aging.

MOTS-cMitochondrial + AMPK + nuclear
MetforminComplex I → AMPK only
ExerciseAMP:ATP ratio → AMPK

What Researchers Observed

42%
Glucose tolerance improvement
Lee et al. (2015) diet-induced obesity mouse model
Glucose tolerance (DIO mice)42%
Fat mass reduction (HFD)35%
Insulin sensitivity improvement38%
Exercise capacity enhancement28%
Key Milestones Achieved
AMPK phosphorylation (skeletal muscle)78%
Confirmed via Western blot
Age-related insulin resistance reversed62%
Old mice treated with MOTS-c
Centenarian variant association55%
m.1382A>C enriched in long-lived
For context:Lee et al. (Cell Metabolism, 2015) identified MOTS-c as a mitochondrial-encoded peptide that regulates insulin sensitivity and metabolic homeostasis via AMPK. Circulating MOTS-c declines with age in human plasma and is lower in type 2 diabetes patients. The m.1382A>C variant is associated with exceptional longevity in Japanese populations (Fuku et al. 2015).
Trial details: Lee et al. 2015: DIO mice, IP injection, metabolic phenotyping · Fuku et al. 2015: centenarian genetics, n=672 · Kim et al. 2018: exercise-mimetic analysis
Sources: Cell Metab (2015) doi:10.1016/j.cmet.2015.02.009 · Aging (2015) doi:10.18632/aging.100759 · Nat Commun (2023) doi:10.1038/s41467-023-36898-2 · J Transl Med (2023) doi:10.1186/s12967-022-03866-9

Compound Information

Technical specifications

🧪 Molecular Profile

What Is MOTS-c?

TypeMitochondrial-derived peptide
CAS Number1627580-64-6
Molecular Weight2,174.6 g/mol
Amino Acids16
FormulaC101H152N28O22S2
❄️ Storage Requirements

Stability Information

Avoid freeze/thaw cyclesProtect from lightKeep refrigerated
Lyophilized (powder)
-20°C · 24+ months
Reconstituted
2-8°C · ~14 days
📋 Development Status

Where It Stands

PreclinicalResearch Use Only
DeveloperUSC (Lee Lab)
Trial ProgramGeroscience research
ResultsPreclinical + human correlative
This page summarizes published research for informational purposes only. These products are sold exclusively as research chemicals and are not intended for human consumption. Always consult peer-reviewed literature for complete study details.

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